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- CAS Registry #:128517-07-7
- Formula:C24H36N4O6S2
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| Description: |
Romidepsin, also known as FK228 or depsipeptide, is a potent and selective inhibitor of HDAC1 and HDAC2 , which are associated with the regulation of re-expression of silenced tumor suppressor genes. It was the first HDAC inhibitor to manifest anti-tumor |
| Synonym(s): |
Istodax; FK228; FR 901228, FK-228; Romidepsin; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone |
| Purity: |
≥98% by HPLC |
| Biological Activity: |
The IC50 for HDAC1 is 36 nM and the IC50 for HDAC2 is 47 nM |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. McGraw AL. Am J Health Syst Pharm. 2013 Jul 1;70(13):1115-22.
2. Kim M, et al. Ann Pharmacother. 2012 Oct;46(10):1340-8.
3. Horwitz SM. Clin Adv Hematol Oncol. 2012 May;10(5):333-4.
4. VanderMolen, KM, et al. J. Antibiotics 2011: 64, 525-531. |
| Scientific Category: |
Romidepsin (FK228, depsipeptide) |
| Product Type: |
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