Methyltransferase(s)

Methyltransferases are enzymes that transfer a methyl group from S-adenosylmethionine (SAM) to their substrates. DNA methylation plays a crucial role in the development of cancer. Histone methyltransferases methylate lysines and arginines on histone side chains.

Several histone methyltransferases have been linked to cancer; one example is lysine methyltransferase EZH2. Abnormal expression of EZH2 has been linked to breast, prostate, endometrial, and other human cancers. Several point mutations in EZH2 cause it to hypermethylate H3K27, and are associated with non-Hodgkins lymphomas and leukemias. In our portfolio, we have several EZH2 mutant enzymes to aid the research.

We offer assay kits, inhibitors/activators, and substrates including purified full-length histone proteins, tetramers, octamers, nucleosomes, and a number of modified histones.

 

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