“A bromodomain is protein domain (~110 amino acid) that binds to acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices.

In humans there are 46 sets of chromatins that contain a total of 61 bromodomains. A well-known example of a bromodomain family is the BET (Bromodomain and extraterminal domain family). Key BRD-containing proteins include Brd2, Brd3, BRD4 and Brdt. Dysfunction of BRD proteins has been linked to diseases such as human squamous cell carcinoma and other forms of cancer.”


  1. Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

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