- Species:Human
- MW:242 kDa (calc.)
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| Description: |
Stable recombinant HEK293 cell line expressing human Nav1.7 (GenBank # Q15858; tetrodotoxin-sensitive voltage-gated sodium channel type IX subunit alpha (SCN9A)). A synthetic codon-optimized DNA sequence encoding human NaV1.7 protein with C-terminal Strep |
| UniProt |
Q15858 |
| Synonym(s): |
Nav1.7, SCN9A, tetrodotoxin-sensitive voltage-gated sodium channel type IX subunit alpha |
| Supplied As: |
Each vial contains ~2 X 106 cells in 1 ml of 10% DMSO. |
| Biological Activity: |
Functionally validated by Western blotting of NaV1.7 using anti-Sodium channel Nav1.7, clone N68/6 (Millipore, #MABN41) and Alkaline Phosphatase conjugated anti-mouse IgG. Also validated for NaV1.7 expression on the cell surface, measured by flow cytometry (FACS) using anti-NaV 1.7 clone 68/6 and PE-labeled anti-mouse IgG. |
| Host Cell line: |
HEK293 cells |
| Instructions for use: |
See cell line data sheet for detailed culturing and assay protocol. |
| Storage / Stability: |
Store in liquid nitrogen immediately upon receipt. |
| Application(s): |
•Screen for activators or inhibitors of Nav1.7
•Functional assays for Nav1.7
•Efficient antigen for mouse immunization |
| Reference(s): |
1. Catterall, W.A. Cell and Developmental Biology 16: 521 |
| Notes: |
Contact us for pricing. License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit the use of this cell line in humans or for therapeutic or drug use. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. Publications using this cell line should reference West Bioscience, Inc., San Diego. |
| Warning(s): |
Avoid freeze/thaw cycles |
| Scientific Category: |
Recombinant Cell Lines(s) |
| Product Type: |
Ion Channel |
