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- CAS Registry #:156192-32-4
- Formula:C30H38N6O6
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| Description: |
The fluorogenic Cathepsin V substrate is a Z-Leu-Arg-AMC dipeptide. It can be used as a substrate for activity assays of Cathepsins K, L, S, and V. λex 353-380 nm, λem=440-460 nm |
| Synonym(s): |
Z-Leu-Arg-AMC, Z-LR-AMC, Benzyloxycarbonyl- L-leucyl- L-arginine 4-methylcoumaryl-7-amide |
| Supplied As: |
0.5 mM solution in DMSO (100 |
| Format: |
DMSO solution |
| Storage / Stability: |
Stable at least 6 months from date of receipt, when stored as directed |
| Application(s): |
Useful for the study of cathepsin activity, and for screening small molecule inhibitors of cathepsins K, L, S, and V for drug discovery and HTS applications. |
| Reference(s): |
1. Fonovic, M. et al., Biol Chem 385(6), 505-509 (2004).
2. D. Broemme, et al. J. Biol. Chem., 271, 2126 (1996). |
| Notes: |
Can also be used as a substrate for human tissue kallikrein, and the falcipains I - III, the hemoglobin-degrading cysteine proteases from the malaria parasite Plasmodium falciparum . |
| Warning(s): |
Protect from direct exposure to light. Avoid freeze/thaw cycles. |
| Scientific Category: |
Protease(s) |
| Product Type: |
Substrates |
