|
|
- CAS Registry #:73963-72-1
- Formula:C20H27N5O2
|
| Description: |
Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 µM and inhibitor of adenosine uptake. |
| Background: |
Cilostazol (OPC-13013, Pletal) is a 2-oxo-quinoline derivative with antithrombotic, vasodilator, antimitogenic and cardiotonic properties. Cilostazol is used in the treatment of peripheral arterial disease and claudication (leg cramps). Cilostazol inhibits platelet aggregation and is a direct arterial vasodilator. |
| Synonym(s): |
Pletal; OPC-13013 |
| Solubility: |
Soluble in DMSO (18 mg/ml). |
| Format: |
white to off-white crystals |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.
2. Liu Y, et al. Cardiovasc Drug Rev, 2001, 19(4), 369-386. |
| Scientific Category: |
Phosphodiesterase(s) |
| Product Type: |
Inhibitors / Activators |
