PD-1:PD-L2[Biotinylated] Inhibitor Screening Colorimetric Assay

Description: Cell signaling through the PD-1 receptor upon binding the PD-L2 ligand attenuates immune responses and is exploited by both tumors and viruses. The PD-1:PDL2[ Biotinylated] Inhibitor Screening Colorimetric Assay Kit is designed for screening inhibitors
Synonym(s): Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L and Programmed Cell Death 2 Ligand 2, PDL2, PD-L2, CD273, PDCDL1G2, B7-DC
Supplied As: This kit comes in a convenient 96-well format, with biotin-labeled PD-L2, purified PD-1, streptavidin-labeled HRP, and assay buffer for 100 binding reactions.
Instructions for use: See assay kit data sheet for detailed protocol.
Storage / Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Application(s): This kit is most useful for screening for inhibitors of PD1 binding to PD-L2.
Reference(s): 1. Molnar, E., et al. Proc Natl Acad Sci U.S.A. 2008, 105: 10483-10488. 2. Keir, M.E., et al. Annu. Rev. Immunol. 2008, 26: 677-704.
Warning(s): Avoid freeze/thaw cycles.
Scientific Category: PD-1:PD-L2[Biotinylated] Inhibitor Screening Colorimetric Assay
Product Type: