| Description: | Cell signaling through the PD-1 receptor upon binding the PD-L2 ligand attenuates immune responses and is exploited by both tumors and viruses. The PD-1:PDL2[ Biotinylated] Inhibitor Screening Colorimetric Assay Kit is designed for screening inhibitors |
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| Synonym(s): | Programmed cell death 1, PDCD1, PD-1, PD1, SLEB2, CD279, HPD-L and Programmed Cell Death 2 Ligand 2, PDL2, PD-L2, CD273, PDCDL1G2, B7-DC |
| Supplied As: | This kit comes in a convenient 96-well format, with biotin-labeled PD-L2, purified PD-1, streptavidin-labeled HRP, and assay buffer for 100 binding reactions. |
| Format: | |
| Instructions for use: | See assay kit data sheet for detailed protocol. |
| Storage / Stability: | Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. |
| Application(s): | This kit is most useful for screening for inhibitors of PD1 binding to PD-L2. |
| Reference(s): | 1. Molnar, E., et al. Proc Natl Acad Sci U.S.A. 2008, 105: 10483-10488. 2. Keir, M.E., et al. Annu. Rev. Immunol. 2008, 26: 677-704. |
| Warning(s): | Avoid freeze/thaw cycles. |
| Scientific Category: | PD-1:PD-L2[Biotinylated] Inhibitor Screening Colorimetric Assay |
| Product Type: | |