| Description: | The PCSK9[Biotinylated]-LDLR Binding Assay Kit is designed for screening and profiling purposes. The key to this kit is the high sensitivity of detection of biotin-labeled PCSK9 by streptavidin-HRP. Only a few simple steps on a microtiter plate are requir |
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| Synonym(s): | pcsk9, cholesterol, LDL, kexin |
| Supplied As: | The PCSK9[Biotinylated]-LDLR Binding Assay Kit comes in a convenient 96-well format, with biotin-labeled PCSK9, purified LDLR ectodomain, streptavidin labeled HRP, and assay buffer for 96 binding reactions. |
| Contraindications: | DMSO >1%, strong acids or bases, ionic detergents, high salt |
| Format: | |
| Instructions for use: | See data sheet for detailed protocol. |
| Storage / Stability: | Mixed storage conditions. Stable at least 12 months from date of receipt, when stored as directed |
| Application(s): | Great for screening small molecules and antibodies that inhibit the binding of PCSK9 to LDLR ectodomain. |
| Reference(s): | 1. Chan, J.C. et al. (2009). Proc. Natl Acad. Sci. USA, 106, 9820-9825. 2. Liang, H., et al. (2012) J. Pharmacol. Exp. Ther. 340 2289-236 |
| Warning(s): | Avoid freeze/thaw cycles |
| Scientific Category: | Other Proteins |
| Product Type: | Assay Kits |