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- CAS Registry #:1035227-43-0
- Formula:C29H38Cl2N4O4
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| Description: |
AZ505 is a potent and highly selective inhibitor of the oncogenic protein SET and MYND domain-containing 2 protein (SMYD2). Exhibits over 600 fold specificity for SMYD2 vs. SMYD3, DOT1L, EZH2, and other histone methyltransferases. |
| Synonym(s): |
N-cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]propanamide |
| Biological Activity: |
AZ505 selectively inhibits the enzymatic activity of SMYD2 (IC50: 0.12 µM) over a variety of other protein lysine methyltransferases (IC50 > 83.3 µ?), including SMYD3, DOT1L, EZH2, GLP, G9A and SET7/9 |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
Ferguson AD, et al. Structure. 2011 Sep 7;19(9):1262-73. |
| Scientific Category: |
Methyltransferase(s) |
| Product Type: |
Inhibitors / Activators |
