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- CAS Registry #:252917-06-9
- Formula:C22H18Cl2N8
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| Description: |
CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor that can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β). |
| Synonym(s): |
CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile |
| Purity: |
≥98% by HPLC |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. |
| Reference(s): |
1. Ring et al (2003). Diabetes 52 588.
2. Pan et al (2011). Neuropsychopharmacology 36 1397.
3. Ye et al (2012). PLoS One 7 e35892. |
| Scientific Category: |
Kinase(s) |
| Product Type: |
Kinase Inhibitors |
