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- CAS Registry #:439081-18-2
- Formula:C24H25ClFN5O3
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| Description: |
Afatinib, also known as BIW-2992, is an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinases. Afatinib suppresses EGF-induced EGFR phosphorylation and cellular proliferation in various cell lines, includin |
| Synonym(s): |
BIW-2992 |
| Purity: |
≥95% by HPLC. |
| Biological Activity: |
Afatinib inhibited the EGFR kinase (IC50 = 15 nM) using West Bioscience EGFR assay performed using 10 |
| Solubility: |
Soluble in DMSO at 200 mg/ml; soluble in ethanol at 25 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 |
| Format: |
White crystalline powder. |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
Eskens, F.A., et al. Br. J. Cancer 98: 80-85 (2008). |
| Scientific Category: |
Kinase(s) |
| Product Type: |
Kinase Inhibitors |
