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- CAS Registry #:1211877-36-9
- Formula:C26H41N3O5
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| Description: |
(R)-MG132 is a potent, cell permeable and reversible inhibitor of proteasomes. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. In comparison to (S)-MG132, the (R)-MG132 stereoisomer is a more eff |
| Purity: |
≥98% by HPLC |
| Biological Activity: |
(R)-MG132 inhibits ChTL, TL and PGPH with IC50 values of 0.22 |
| Solubility: |
Soluble in ethanol, DMSO and DMF, purged with an inert gas. Solubility in these solvents is approximately 25 mg/ml |
| Format: |
A crystalline solid. |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Lee, D.H., et al., Trends Cell Biol. 1998;8:397-403
2. Elliot, P.J., et al., J. Mol. Med. 2003;81:235-245
3. Mroczkiewicz, M., et al., J. Med. Chem. 2010;53:1509-1518. |
| Scientific Category: |
Inhibitors / Activators |
| Product Type: |
Ubiquitination |
