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- CAS Registry #:747412-49-3
- Formula:C26H31N3O5
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| Description: |
AUY922 (NVP-AUY922) is a potent, novel synthetic resorcinylic isoxazole amide inhibitor of heat shock protein 90 (HSP90). It has a high affinity for Hsp90, binding to the ATP binding site of Hsp90 at the N-terminal domain. AUY922 has shown promising acti |
| Synonym(s): |
VER-52296; AUY-922; AUY 922; NVP-AUY922 |
| Biological Activity: |
NVP-AUY922 potently inhibits the proliferation of gastric cancer cell lines with with GI50 values of approximately 2 to 40 nmol/L and significantly induces the degradation of growth factor receptors and other client proteins. NVP-AUY922 significantly suppressed the activity of AKT and ERK and potently induced antiproliferation in ESCC cells. |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Scientific Category: |
Inhibitors / Activators |
| Product Type: |
Protease |
