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- CAS Registry #:28097-03-2
- Formula:C30H28N6O6S4
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| Description: |
Chaetocin is an inhibitor of histone methyltransferases (HMTs) including SUV39H1 and Lys9-specific HMTs such as G9a. It also has some inhibitory effects on SET7, EZH2, and SET7/9. Chaetocin can also induce cellular oxidative stress, selectively killing ca |
| Purity: |
≥95% by HPLC |
| Biological Activity: |
Chaetocin inhibits SUV39H1 with an IC50 = 0.8 |
| Solubility: |
Soluble in organic solvents purged with an inert gas and solubility is 25 mg/ml. |
| Format: |
A crystalline solid. |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Greiner, D., et al., Nat. Chem. Biol. 2005;1(3):143-145.
2. Isham, C.R., et al., Blood 2007;109(6):2579-2588.
3. Tibodeau, J.D., et al., Antioxid. Redox Signal. 2009;11(5):1097-1106. |
| Scientific Category: |
Inhibitors / Activators |
| Product Type: |
Methyltransferase |
