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- CAS Registry #:935693-62-2
- Formula:C28H38N6O2 • 3HCl [XH2O]
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| Description: |
BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a, a histone methyltransferase (HMT). It can also inhibit G9a-like protein (GLP), but is less effective. There are no known inhibitory effects on other HMTs. Also, BIX01294 has been used in co |
| Purity: |
≥98% by HPLC |
| Biological Activity: |
BIX01294 inhibits G9a with an IC50 = 1.7 |
| Solubility: |
Dissolve in water or other aqueous buffers. Solubility in water is ~20 mg/ml. |
| Format: |
A crystalline solid. |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Tachibana, M., et al., Genes Dev. 2002; 16:1779-1791.
2. Wagschal, A., et al., Mol. Cell. Biol. 2008; 28(3):1104-1113.
3. Thomas, L.R., et al., J. Immunol. 2008; 181:485-493. |
| Scientific Category: |
Inhibitors / Activators |
| Product Type: |
Methyltransferase |
