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- CAS Registry #:1149705-71-4
- Formula:C29H37N5O3
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| Description: |
XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90α and HSP90β with IC50s of 22 nM and 44 nM respectively. It also exerts considerably weaker inhibition against a range of other |
| Synonym(s): |
Xl 888; Xl888; 2-(butan-2-ylamino)-4-N-[(1R,5S)-8-[5-(cyclopropanecarbonyl)pyridin-2-yl]-8-azabicyclo[3.2.1]octan-3-yl]-5-methylbenzene-1,4-dicarboxamide |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Paraiso KH, et al. Clin Cancer Res. 2012; 18(9):2502-2514.
2. Bussenius J, et al. Bioorg Med Chem Lett. 2012; 22(17): 5396-5404. |
| Scientific Category: |
Inhibitors / Activators |
| Product Type: |
Metabolic Enzymes |
