- Species:Human
- Host Species:Freestyle 293 cells
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| Description: |
Neutralizing recombinant human monoclonal antibody recognizing the extracellular domain of PD-L1 and blocking the binding of PDL1 to PD-1. This antibody has been shown to cross-react with mouse PD-L1. No other species have been tested. |
| Synonym(s): |
Programmed Cell Death 1 Ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, CD274, PDCD1L1 |
| Endotoxin Level: |
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| Specific Activity: |
IC50 = 11 nM |
| Assay Conditions: |
Antibody was added to PD- 1:PD-L1 binding assay at various concentrations. Assay was done according to BPS Cat. #72003 protocol. |
| Formulation: |
8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol |
| Purification: |
Protein A affinity chromatography from HEK293 supernatants. |
| Format: |
Aqueous buffer solution. |
| Storage / Stability: |
Stable for at least 12 months at -80 |
| Application(s): |
Useful for inhibition of PD1:PD-L1 interactions. |
| Reference(s): |
1. Freeman, G.J., et al., J. Exp. Med. 2000; 192(7): 1027-1034.
2. Dong, H., et al., Nat. Med. 1999; 5(12): 1365-1369. |
| Warning(s): |
Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 |
| Scientific Category: |
Immunotherapy |
| Product Type: |
Antibodies |
