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- CAS Registry #:908112-43-6
- Formula:C23H27F3N4O3
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| Description: |
SNX-2112 is an ATP-competitve inhibitor of both Hsp90α and Hsp90β heat shock protein. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and exhibits antican |
| Synonym(s): |
4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide |
| Purity: |
≥98% by HPLC |
| Biological Activity: |
SNX-2112 selectively binds to the ATP pocket of Hsp90 family members Hsp90α (Ka = 30 nM) and Hsp90β (Ka = 30 nM). Cell lines studied demonstrates sensitivity to SNX-2112 (IC50 =10-100?nM). |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Scientific Category: |
Heat Shock Proteins |
| Product Type: |
Inhibitors / Activators |
