| Description: | The EZH2 Direct Activity Chemiluminescent Assay Kit is designed to measure activity of the EZH2 complex (EZH2/EED/SUZ12/RbAp48/AEBP) for screening and profiling applications. The key to the EZH2 Direct Activity Assay Kit is a highly specific antibody t |
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| Background: | EZH2 is a histone methyltransferase that exhibits methylation activity toward H3-K27. |
| Synonym(s): | KTM6A, EZH2, PRC2, Enhancer Of Zeste Homolog 2, EZH |
| Supplied As: | Kit comes in a convenient format, with a 96-well plate precoated with histone H3 peptide substrate, reagents, and purified EZH2 complex for 100 enzyme reactions. |
| Contraindications: | DMSO >1%, strong acids or bases, ionic detergents, high salt |
| Format: | |
| Instructions for use: | See assay kit data sheet for detailed protocol. |
| Storage / Stability: | 12 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. |
| Application(s): | Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications. |
| Reference(s): | Dillon S.C., et al. 2005. Genome Biology 6:227. |
| Warning(s): | Avoid freeze/thaw cycles. |
| Scientific Category: | EZH2 Chemiluminescent Assay Kit |
| Product Type: | |