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- CAS Registry #:935881-37-1
- Formula:C8H20N2O3
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| Description: |
(S)-HDAC-42 is a strong inhibitor of HDACs. It decreases the viability of prostate cancer cell lines by increasingthe expression of p21 and the acetylation of histone H3 while decreasing Akt phosphorylation and Bcl-XL expression. The inhibitor suppresses |
| Purity: |
≥95% by HPLC |
| Biological Activity: |
(S)-HDAC-42 inhibits HDACs with IC50 = 16 nM in vitro. |
| Solubility: |
Soluble in ethanol, DMSO and DMF, which should be purged with an inert gas. Solubility in these solvents is ~20 mg/ml. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers. |
| Format: |
A crystalline solid |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Lu, Q., et al., J. Med. Chem. 2005; 48: 5530-5535
2. Kulp, S.K., et al., Clin. Cancer Res. 2006; 12(17): 5119-5206. |
| Scientific Category: |
Deacetylase(s) |
| Product Type: |
Inhibitors / Activators |
