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- CAS Registry #:935881-37-1
- Formula:C18H20N2O3
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| Description: |
AR-42 (also known as OSU-HDAC42), a derivative of hydroxamate-tethered phenylbutyrate is a broad-spectrum deacetylase inhibitor of both histone and non-histone proteins. AR-42 treatment induces histone hyperacetylation and p21WAF/CIP1 overexpression, in |
| Synonym(s): |
OSU-HDAC42; N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide |
| Purity: |
≥99% by HPLC |
| Biological Activity: |
AR-42 is a pan-HDAC inhibitor with IC50 of 16-30 nM. It has demonstrated greater potency and activity in solid tumors and hematological malignancies (including chronic lymphocyte leukemia, or CLL, B-cell lymphoma, prostate and ovarian cancers) when compared to vorinostat (SAHA), the first of two marketed compound in the class. |
| Solubility: |
Soluble in DMSO |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Burns, S.S., et al. Cancer Res. 2013 Jan 15;73(2):792-803.
2. Zhang, S., et al. Int J Cancer. 2011 Jul 1;129(1):204-13.
3. Lucas, D.M., et al. PLoS One. 2010 Jun 3;5(6):e10941 |
| Scientific Category: |
Deacetylase(s) |
| Product Type: |
Inhibitors / Activators |
