|
|
- CAS Registry #:467214-21-7
- Formula:C32H48N4O8 • HCl
|
| Description: |
Alvespimycin HCl, also known as 17-DMAG, is a potent, water-soluble HSP90 inhibitor. Alvespimycin has diverse anti-tumor actions and has potential in treating a number of different types of cancers, including ovarian, prostate, melatnoma, non-small-cel |
| Synonym(s): |
17-DMAG; KOS-1022; NSC707545; 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin |
| Purity: |
≥95% by HPLC |
| Biological Activity: |
Alvespimycin (also known as 17-DMAG) displays ~2 times potency against human Hsp90 than 17-AAG, with IC50 of 62 nM versus 119 nM. |
| Solubility: |
Soluble in DMSO (100 mM). Solubility in water is less than 1 mg/ml (1 mM). |
| Storage / Stability: |
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Reference(s): |
1. Smith V et al. Cancer Chemother Pharmacol. 2005 Aug;56(2):126.
2. Lancet JE, et al. 2010 Apr;24(4):699-705. |
| Scientific Category: |
Alvespimycin HCl (17-DMAG) |
| Product Type: |
|
