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- CAS Registry #:1402836-58-1
- Formula:C18H22N2O
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Description: |
NLG919 is an orally available potent inhibitor of the indoleamine-(2,3)- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 a |
Synonym(s): |
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol |
Purity: |
≥98% |
Biological Activity: |
NLG919 potently blocks IDO-induced T cell suppression and restored T cell responses with a reported ED50 of 80 nM in vitro. NLG919 reduced the concentration of plasma and tissue kynurenine by ~50% after a single dose in mice. NLG919 enhanced the antitumor responses of na |
Solubility: |
Soluble in DMSO at 15 mg/ml. |
Format: |
White powder |
Storage / Stability: |
Store as supplied at or below -20 |
Reference(s): |
1. Driessens, G., et al., J. Immunother. Cancer. 2014; 2(Suppl 3):195.
2. Nayak, A., et al. J. Immunother. Cancer. 2014; 2(Suppl 3): 250. |
Scientific Category: |
NLG919 |
Product Type: |
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