Description: NLG919 is an orally available potent inhibitor of the indoleamine-(2,3)- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 a
Synonym(s): 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Purity: ≥98%
Biological Activity: NLG919 potently blocks IDO-induced T cell suppression and restored T cell responses with a reported ED50 of 80 nM in vitro. NLG919 reduced the concentration of plasma and tissue kynurenine by ~50% after a single dose in mice. NLG919 enhanced the antitumor responses of na
Solubility: Soluble in DMSO at 15 mg/ml.
Format: White powder
Storage / Stability: Store as supplied at or below -20
Reference(s): 1. Driessens, G., et al., J. Immunother. Cancer. 2014; 2(Suppl 3):195. 2. Nayak, A., et al. J. Immunother. Cancer. 2014; 2(Suppl 3): 250.
Scientific Category: NLG919
Product Type: