Bromodomain(s)

Bromodomains1
Bromodomains2

“A bromodomain is protein domain (~110 amino acid) that binds to acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. The domain itself adopts an all-α protein fold, a bundle of four alpha helices.

In humans there are 46 sets of chromatins that contain a total of 61 bromodomains. A well-known example of a bromodomain family is the BET (Bromodomain and extraterminal domain family). Key BRD-containing proteins include Brd2, Brd3, BRD4 and Brdt. Dysfunction of BRD proteins has been linked to diseases such as human squamous cell carcinoma and other forms of cancer.”

References:

  1. Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.
  2. http://en.wikipedia.org/wiki/Bromodomain

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